Kafedraning ilmiy ishlari
Kafedraning ilmiy tematikasi:
- Ikkilamchi immuntanqisligining molekulyar asoslari va ularni korrektsiyalash usullari.
- Biologik membranalarni zararlanishining molekulyar mexanizmlari.
- Biogen elementlarni ligandlar bilan komplekslari asosida biologik faol birikmalar sintezi.
Oxirgi 5 yilda kafedra xodimlari tomonidan 3 monografiya, 16 o’quv-uslubiy qo’llanma, hamda usubiy tavsiyanoma va axborot xatlari chop etilgan.
Oxirgi 5 yillikda chop etilgan monografiyalar
№ |
Title |
Author |
Edition |
Year of publication,page |
1. |
Biologik sistemalarda kislorodning erkin radikallarning tasiri wa HIMOYA mehanizmlari |
Soatov TS, |
Publishing Department TashPMI |
2009 |
2. |
Biological membranes |
Ibragimov WC, |
Publishing Department TashPMI |
2009 |
3 |
Effects of active oxygen species and antioxidants (in Russ. language) |
Nazirov FG, Ibragimov UK, Khaibullina ZR |
Published by: LAP LAMBERT Academic Publishing ist ein Imprint der / is a trademark OmniScriptum GmbH & Co.KG I leinrich-Bficking-Str. 6-8, 66121 Saarbriicken, Deutschland / Germany |
2014, 1-100 b. |
Kafedra xodimlari o’z ilmiy ishlari natijalarini «O’zbekiston tibbiyot jurnali», «Patologiya», «Infeksiya, immunitet va farmakologiya», «Pediatriya», «O’zbekiston biologiya jurnali» kabi yuqori reytingli mahalliy jurnallarda, hamda yetakchi restenziyalanadigan jurnal va to’plamlarda chop etadilar.
Kafedra xodimlari TashPMI institutida, Respublika va Xalqaro konferensiyalarda ma’ruzalar bilan ishtirok etadilar.
Ulardan asosiylari quyidagi jurnal maqolalar bo'lgan:
Kafedraning ilmiy nashrlar
2017
1. Khaybullina ZR. Synthetic Antioxidants and Its Effects in Ultra Low Concentrations, Probability of Cardio Protection by Membrane Stabilization // Journal of Cardiology & Cardiovascular Therapy. № 4(5), 2017, рр. 1-2. (article, Europe).
2. Nishantaev MK, Yuldashev NM, Kamolova AA, Atavullaeva MA. The hypolipidemic property of a substance based on silk fibroin // Journal of Young Scientist. No. 13 (147), Part II, 2017, рр. 139-141. (article, CIS).
3. Akbahodzhayeva Kh.N., Alimkhodzhaeva NT, Muzaffarhonov Sh.M. The content of phospholipids in immunocompetent cells of experimental rats // Journal of Young Scientist. No. 16 (150), Part I, 2017, рр. 5-7. (article, CIS).
4. Ismailova GO, Yuldashev NM, Rakhimova GR, Harisova I.I. Contribution of the nucleus and substituents of synthesized derivatives of 2'-substituted chalcons to the activity of substances with regard to their position // Journal of Almanac of Modern Science and Technology Education, No. 2 (116), 2017, pp. 55-60. (article, CIS).
5. Akbarhodzhaeva Kh.N., Alimkhodzhaeva NT, Minavarova Sh.A., Bizhanova AB. The change in the phospholipid (PL) composition of the liver and immunocompetent organs of rats during xenobiotic intoxication // Journal of Young Scientist. No. 16 (150), Part I, 2017, рр. 1-5. (article, CIS).
6. Ziyamutdinova ZK, Akbarkhodzhaeva Kh. N., Yuldashov SI, Masharipov I.O. Correcting effect of membrane stabilizers and antioxidants // Journal of Young Scientist. No. 14 (148), Part III, 2017, pp. 225-227. (article, CIS).
7. Karimova Sh.F., Yuldashev NM, Ismayilova GO, Nozimshiniyeva MA. Sensitivity of thyroidocytes of growing rats to thyroid-stimulating hormone of pituitary gland with different iodine maintenance // Journal of Pediatrics. № 1, 2017, pр.138-139. (article, L).
8. Ismailova G.O. Pedagogical innovative technology of a subject of biochemistry on the basis of modular training // "Application and efficiency of modern technologies in the higher medical education" Republican educational-methodical conference. Collection of articles and abstracts. January 6, 2017. TashPMI. Tashkent. Pp. 228-235. (article, L).
9. Ismailova GO, Yuldashev NM. Application and effectiveness of modern technologies in higher medical education of independent work of students on modular training // "Application and efficiency of modern technologies in higher medical education" Republican educational-methodical conference. Collection of articles and abstracts. January 6, 2017. TashPMI. Tashkent. pp. 235-240. (article, L).
10. Ziyamutdinova ZK, Akbarhodzhaeva Kh.N., Janalieva G.A. "Eritmalarni tibbyotdagi ahamiyati" Mavzusini pedagogy tekhnolar vositasida tashkil kilish // "Application and efficiency of modern technologies in higher medical education" Republican educational and methodical conference. Collection of articles and abstracts. January 6, 2017. TashPMI. Tashkent. Pp. 201-203. (article, L).
11. Ismailova G.O., Suleymanova G.G., Madiev Yu.R. Classical method of quantitative determination of the total amount of biologically active coumarinic components in the plant organs of white melon // Periodical scientific collection "Modern trends in the development of science and technology" based on the materials of the XXII International Scientific and Practical Conference, Belgorod, January 31, 2017, No. 1, part 2, pp. 70-72. (thesis, CIS).
12. Ismailova GO, Bakhodirova M.O. Biological activity of 3-amino, 6-fluoro-3 ', 4'-ethylenedioxyflavone // "Trends and innovations of modern science" materials of the XIX International Scientific and Practical Conference (March 29, 2017). Theses of reports, Krasnodar. p. 30. (Thesis, CIS).
13. Ismailova GO, Solibaeva NO, Eldosheva P.Zh. Hepatoprotective activity of 3-amino, 6-fluoro-3', 4'-ethylenedioxyflavone. // "Trends and Innovations of Modern Science" materials of the XIX International Scientific and Practical Conference (March 29, 2017). Theses of reports, Krasnodar. 29. (Thesis, CIS).
14. Ismailova GO, Makhammadkosimova ZB. Cytoprotective activity of 3-amino, 6-chloro-3', 4'-ethylenedioxyflavone // // "Trends and Innovations of Modern Science" materials of the XIX International Scientific and Practical Conference (29 March 2017). Theses of reports, Krasnodar. С. 28. (Thesis, CIS).
2018
1. Alimxodjaeva N.T., Akbarxodjaeva X.N. Bioximicheskaya korreksiya strukturы i funksiy membran pri intoksikatsii gepatotropnыmi ksenobiotikami. // Mejdunarodnыy nauchnыy jurnal «Molodoy uchenыy». – Kazan, Rossiya. – 2018. - №21 (207). – S. 166-169. (statya, SNG).
2. Ismailova G.O. Interaktivnыy novыy metod po bioximicheskim protsessam, protekayuщix v kletkax «chto, gde i kak?» // «Tibbiy ta’limdagi islohotlar – mamlakatimiz tibbiyot sohasining taraqqiyot mezoni», Resp. o‘quv-uslub. konf., ToshPTI. – Toshkent, 2018. –86-87 betlar. (tezis, M).
3. Ismailova G.O., YUldashev N.M. Eksperimentalnыe metodы oprosa pobioximicheskim protsessam, protekayuщix v kletkax. // «Tibbiy ta’limdagi islohotlar – mamlakatimiz tibbiyot sohasining taraqqiyot mezoni», Resp. o‘quv-uslub. konf., ToshPTI. – Toshkent, 2018. –87-88 betlar. (tezis, M).
4. Karimova SH.F. O texnologii ovladeniya predmeta «bioximiya» posredstvom modulnogo obucheniya // «Tibbiy ta’limdagi islohotlar – mamlakatimiz tibbiyot sohasining taraqqiyot mezoni», Resp. o‘quv-uslub. konf., ToshPTI. – Toshkent, 2018. –105-106 betlar. (tezis, M).
5. Rasulova M.T., YUldashev N.M. Jigar monooksigenaza tizimi induktori benzonal ta’sirida qalqonsimon bezning morfologik holati // “Tibbiyotning dolzarb muammolari” talabalar, klinik ordinatorlar va yosh olimlarning XXVilmiy-nazariy anjumani materiallari. – Urganch, 2018. – 378-379 betlar. (tezis, M).
6. Rasulova M.T., YUldashev N.M. Tireodnыy status organizma pri benzonalovoy induksii monooksigenaznoy sistemы (MOS) pecheni // “Tibbiyotning dolzarb muammolari” talabalar, klinik ordinatorlar va yosh olimlarning XXVilmiy-nazariy anjumani materiallari. – Urganch, 2018. – 380 bet. (tezis, M).
Dissertatsiyalar himoyasi
O’tgan davrda 1 doktorlik dissertastiyasi himoya qilindi.
Xaybullina Zarina Ruslanovna 2012 yili Toshkentda O’zR FA Biokimyo institutida «Molekulyarnie mexanizmi povrejdeniya biomembran pod deystviem aktivnix form kisloroda pri gipoksii» mavzusida doktorlik dissertatsiyasini himoya qildi. Ixtisoslik shifri03.00.04 - Biokimyo. D 015.16.01. Ilmiy maslahatchi – tibbiyot fanlari doktori, professor Ibragimov U.K.
Olingan natijalar va ularning yangiligi: postgipoksik davrning olis muddatlarida miya va jigarning a’zolararo o’zaro bog’liqligi hamda uning sterebral ishemiya oqibatlarini chuqurlashtirishdagi hissasi aniqlangan. Postgipoksik davrda jigar mitoxondriyalari fraksiyasidagi fosfolipidlar miqdori buzilishlari hamda KShF ortiqcha generatsiyasining qo’shadigan hissasi va fenozan nanodozalarining antiapoptoz ta’siri aniqlangan; postgipoksiya davrining erta muddatlarida jigar mikrosomalari fraksiyasi membranaviy komponentini postgipoksik adaptatsiya reaksiyalaridagi ishtiroki va alfa-tokoferol nanodozalarining antioksidant sistem (AOS) fermentlariga modullovchi ta’siri aniqlangan. Fenozan nanodozalarini miya to’qimasida AOS fermentativ bo’g’iniga imtiyozli ta’sir etishi orqali fosfolipidlar oksidlanishini pasaytirishi hamda miyani taraqqiy etishi uchun shart-sharoitlarni mutanosiblashtirishi aniqlangan.
Amaliy ahamiyati: chaqaloqlarda sterebral ishemiya og’irligini bashoratlash shkalasi ishlab chiqilgan, tajribadagi homila gipoksiyasida antioksidantlar nanodozalarini qo’llash asoslab berilgan.
Tatbiq etish darajasi va iqtisodiy samaradorligi: olingan natijalar RIIATM Akusherlik va ginekologiya, RIIATM Pediatriya, ToshPTI, ToshVMOI uslubiy tavsiyanomalar va axborot xati shaklida joriy qilingan.
Qo’llanilish sohasi: biokimyo, pediatriya.
Kafedraning o’zaro aloqalari
Kafedra ilmiy ishlarni olib borishda TTA biokimyo kafedrasi, ToshVMOI klinik va laborator diagnostikasi kafedrasi, O’zR FA Bioorganik kimyo instituti, RFA Biokimyoviy fizika instituti (Moskva), TTA Urganch filiali biokimyo kafedrasi bilan hamkorlik qiladi.
Grantlar, ilmiy tashkilotlar va redaksion kengashlardagi a’zoliklar
2012-2014 yillarda kafedrada ADSS 30.3 «Razrabotka sposoba usileniya zajivleniya nekroticheskix porajeniy miokarda v eksperimente» mavzusida grant loyihasi olib borilgan, rahbar – prof. N.M. Yuldashev.
Kafedraning ilmiy salmog’i shu bilan tasdiqlanadiki, akademik Saatov T.S. 10 yil davomida O’zR FA Biokimyo institutidagi doktorlik va kandidatlik himoyalari bo’yicha D 015.16.01 ixtisoslashgan kengashga raislik qildi, professor N.M. Yuldashev 2012 yilgacha TTA qoshidagi doktorlik va kandidatlik himoyalari bo’yicha D 087.09.02 birlashgan ixtisoslashgan kengashda ilmiy kotiblik qildi va hozirda u «O’zbekiston Kardiologiyasi» jurnali redaksion kollegiyasi a’zosi, SSV va O’zR FA eksperti, OO’Yu vazirligining darslik va o’quv-uslubiy qo’llanmalari ekspertizasi bo’yicha ekspert kengashi a’zosi.
Ixtirolar
Sog’liqni saqlash amaliyotiga 1 patent, 5 metodikalik taklifi, 3 informastion xatlar va 1 ratsionalizatorlik taklifi tadbiq etilgan.
Kafedradagi talabalar ilmiy jamiyati
Kafedrada talabalar ilmiy jamiyati hamda «Yosh bioximik» to’garagi mavjud. TIJ a’zolari ilmiy ish bilan faol shug’ullanadilar, natijalarni TIJning Institut ToshPTIda, respublika va Xalqaro konferensiyalarida tezislar shaklida chop etadilar. «Yosh bioximik» to’garagining ilmiy yo’nalishi: “Turli kasalliklarda organizmda erkin-radikal jarayonlari”.
Talabalar ilmiy jamiyati ilmiy nashrlari
2017 - 2018
1. Bahodirova MO, 211-guruh, II-pediatriya fakulteti. Ilmiy maslahatchi: Ismailova G.O. Flavonoidonosnoe o't O'zbekistonning // "Xalq Bilan Muloqot alayhi inson manfaatlari va yoki" ga bagishlangan Talabalar ilmy zhamiyatining 45 - ilmy - Amal anzhumani tezislar tuplyu. Toshkent, 20 aprel, 2017 yil. 90-bet. (Tezis, M).
2. Harisova II, 313-guruh, I-pediatriya fakulteti. Ilmiy maslahatchi: Ismailova G.O. "Xalq Bilan Muloqot alayhi inson manfaatlari va yoki" // sintez kalgon türevini Bioscreening ga bagishlangan Talabalar ilmy zhamiyatining 45 - ilmy - Amal anzhumani tezislar tuplyu. Toshkent, 20 aprel, 2017 yil. S. 475. (tezis, M).
3. Kamolova AA, 212-guruh, II-pediatriya fakulteti. Ilmiy maslahatchi: Yuldashev NM uning molekulyar tuzilishi // "Xalq Bilan jurnali Muloqot alayhi inson manfaatlari va yoki" munosabati bilan ipak fibroin asosida dori yutilish quvvatiga tahlili ga bagishlangan Talabalar ilmy zhamiyatining 45 - ilmy - Amal anzhumani tezislar tuplyu. Toshkent, 20 aprel, 2017 yil. S. 191. (tezis, M).
4. Atavullaeva MA, 212-guruh, II-pediatriya fakulteti. Boshqaruvchi: Nishantaev M.K. xolesterin qarshi ipak fibroin // "Xalq Bilan Muloqot alayhi inson manfaatlari va yoki" asosida dori yutilish salohiyatini o'rganish ga bagishlangan Talabalar ilmy zhamiyatining 45 - ilmy - Amal anzhumani tezislar tuplyu. Toshkent, 20 aprel, 2017 yil. S. 84. (tezis, M).
5. Madiev Yu.R., 206-guruh, tibbiyot-pedagogika fakulteti va tibbiyot biznesi. Boshqaruvchi: Karimova Sh.F. Morfologik rats // emizgan tiroidektomi emizikli keyin rat qalqonsimon o'zgarishlar "Muloqot alayhi inson manfaatlari Xalq Bilan va yoki" ga bagishlangan Talabalar ilmy zhamiyatining 45 - ilmy - Amal anzhumani tezislar tuplyu. Toshkent, 20 aprel, 2017 yil. S. 233. (Tezis, M).
6. Kamolova NN, 210-guruh, I-pediatriya fakulteti. Ilmiy maslahatchi: Ziyamutdinova Z.K. tuzilmaviy birliklari membrana // sifatida gangliosidlet va fosfolipidlar ma'nosi "Xalq Bilan Muloqot inson manfaatlari iili alayhi" n bagishlangan Talabalar ilmy zhamiyatining 45 - ilmy - Amal anzhumani tezislar tuplyu. Toshkent, 20 aprel, 2017 yil. S. 196. (Tezis, M).
7. KarimovaSH.F., Ismailova G.O., Karimova N.M., Bijanova A.B. Eksperimentalnoe issledovanie chuvstvitelnosti kletok щitovidnoy jelezы krыs k tireotropnomu gormonu gipofiza pri razlichnom yodnom obespechenii. // Mejdunarodnыy nauchnыy jurnal «Razvitie i aktualnыe voprosы sovremennoy nauki». – Magnitogorsk, Rossiya. – 2018. - №1 (8). – S. 122-127. (statya, SNG).
8. Alimxodjaeva N.T., Akbarxodjaeva X.N., Tadjibaeva D.SH., Menglieva I.A. Izmenenie aktivnosti fermentov uglevodnogo obmena pri eksperimentalnom gepatite. // Mejdunarodnыy nauchnыy jurnal «Molodoy uchenыy». – Kazan, Rossiya. – 2018. - №21 (207). – S. 159-162. (statya, SNG).
9. Alimxodjaeva N.T., Akbarxodjaeva X.N., Tadjibaeva D.SH., Menglieva I.A. Korreksiya aktivnosti fer-mentov antiokislitelnoy sistemы (SOD, katalazы) pri geliotrinnom gepatite. // Mejdunarodnыy nauchnыy jurnal «Molodoy uchenыy». – Kazan, Rossiya. – 2018. - №21 (207). – S. 163-166. (statya, SNG).
10. Ziyamutdinova Z.K., Sadriddinova M.A., Boltayev B.M. Sorrecting action of membranstabilizers and antioxidants. // Ejemesyachnыy mejdunarodnыy nauchnыy jurnal «INTERNATIONAL SCIENCE PROJECT» - Turku, Finlyandiya. –2018. – 1 chast, №10. –S. 50-52. (statya, SNG).
11. Ismailova G.O., SHoyunusov S.I., Suleymanova G. G. Effektivnыe sposobы sinteza gomologov psevdobaptigenina. // Sbor. mater. XXXVII Mejdunarodnoy nauchno-prakt. konferensiy «Actual scientific research 2018». – Moskva, 2018. – 27 aprel. – S. 74-76. (tezis, SNG).
12. YUldashev N.M., Ismailova G.O., Abdurazzakova R.S. Axborot psixologik xurujlari sharoitida davlat axborot siyosati // «YOshlar bilan muloqot: muammo va echimlar» mavzusidagi Xalqaro ilmiy - amaliy konferensiya materiallari.– Toshkent, 2018. – 25 yanvar. – 246-248-betlar. (tezis, M).
13. YUldashev N.M., Ismailova G.O., Abdurazzakova R.S. YOshlar o‘rtasida xuquqbuzarliklarni oldini olish chora tadbirlari // «YOshlar bilan muloqot: muammo va echimlar» mavzusidagi Xalqaro ilmiy - amaliy konferensiya materiallari.– Toshkent, 2018. – 25 yanvar. – 382-385-betlar. (tezis, M).
14. Sobirova M.G., Ismailova G.O. Peschanaya akatsiya konolli – flavonoidonosnoe lekarstvennoe rastenie Uzbekistana // "Faol tadbirkorlik, innovatsion g‘oyalar va texnologiyalarni qo‘llab-quvvatlash yili " ga bag‘ishlangan ToshPTI, talabalar ilmiy jamiyatining 46-ilmiy-nazariy anjumani tezislar to‘plami. – Toshkent, 2018. – 307-309 betlar. (tezis, M).
15. Lutfullaev F.SH., Karimova SH.F. Razlichnoe yodnoe obespechenie i chuvstvitelnost tireotropotsitov gipofiza krыs k vvedeniyu TTG // "Faol tadbirkorlik, innovatsion g‘oyalar va texnologiyalarni qo‘llab-quvvatlash yili " ga bag‘ishlangan ToshPTI, talabalar ilmiy jamiyatining 46-ilmiy-nazariy anjumani tezislar to‘plami. – Toshkent, 2018. – 182-183 betlar. (tezis, M).
16. SHoyunusov S.I., Karimova SH.F. Otdelnыe parametrы metabolizma plodov i novorojdennыx krыsyat v zavisimosti ot funksionalnogo sostoyaniya щitovidnoy jelezы beremennoy i laktiruyuщey samki // "Faol tadbirkorlik, innovatsion g‘oyalar va texnologiyalarni qo‘llab-quvvatlash yili " ga bag‘ishlangan ToshPTI, talabalar ilmiy jamiyatining 46-ilmiy-nazariy anjumani tezislar to‘plami. – Toshkent, 2018. – 418-419 betlar. (tezis, M).
17. G‘ulomjonov F.SH., Suleymanova G.G. YUrak glikozidlarining tibbiyotdagi axamiyati // "Faol tadbirkorlik, innovatsion g‘oyalar va texnologiyalarni qo‘llab-quvvatlash yili " ga bag‘ishlangan ToshPTI, talabalar ilmiy jamiyatining 46-ilmiy-nazariy anjumani tezislar to‘plami. – Toshkent, 2018. – 455 bet. (tezis, M).
2017-2018 yillarda TIJ konferenstiyalari materiallarida 20 tan kup talabalar ishlari chop etildi (mahalliy va xorijiy nashrlar).
To’garak murabbiy – dotsent Nishantaev M.K.
• Talabalarning ishlari ilmiy materiallarida chop etkanlar ("Yuklab olish" bulimda)