Scientific work of the Department
Scientific program of the Department:
1. Molecular basis of secondary immune deficiencies and ways of their correction.
2. The molecular mechanisms of injury of biological membranes.
3. Synthesis of biologically active compounds based on complexes with ligands of nutrients.
During the last 5 years at the department were published 2 monographs, 16 teaching aids, as well as guidance and newsletters.
Monographs published in the last 5 years
|
№ |
Title |
Author |
Edition |
Year of publication,page |
|
1. |
Biologik sistemalarda kislorodning Erkin radikallarning tasiri wa HIMOYA mehanizmlari |
Soatov TS, |
Publishing Department TashPMI |
2009 |
|
2. |
Biological membranes |
Ibragimov WC, |
Publishing Department TashPMI |
2009 |
|
3 |
Effects of active oxygen species and antioxidants (in Russ. language) |
Nazirov FG, Ibragimov UK, Khaibullina ZR |
Published by: LAP LAMBERT Academic Publishing ist ein Imprint der / is a trademark OmniScriptum GmbH & Co.KG I leinrich-Bficking-Str. 6-8, 66121 Saarbriicken, Deutschland / Germany |
2014, Рр.1-100 |
Of these, the main ones are the following journal articles:Employees of the Department widely publish the results of their research in leading peer-reviewed journals and books, including the top-rated domestic scientific journals such as "The Medical Journal of Uzbekistan", "Pathology", "Infection, Immunity and pharmacology", "Pediatrics", "biochemistry. "
Employees of the department are involved and make presentations at national and international conferences.
Of these, the main ones being the following journal articles:
Scientific publications of the Department
2017
1. Khaybullina ZR. Synthetic Antioxidants and Its Effects in Ultra Low Concentrations, Probability of Cardio Protection by Membrane Stabilization // Journal of Cardiology & Cardiovascular Therapy. № 4(5), 2017, рр. 1-2. (article, Europe).
2. Nishantaev MK, Yuldashev NM, Kamolova AA, Atavullaeva MA. The hypolipidemic property of a substance based on silk fibroin // Journal of Young Scientist. No. 13 (147), Part II, 2017, рр. 139-141. (article, CIS).
3. Akbahodzhayeva Kh.N., Alimkhodzhaeva NT, Muzaffarhonov Sh.M. The content of phospholipids in immunocompetent cells of experimental rats // Journal of Young Scientist. No. 16 (150), Part I, 2017, рр. 5-7. (article, CIS).
4. Ismailova GO, Yuldashev NM, Rakhimova GR, Harisova I.I. Contribution of the nucleus and substituents of synthesized derivatives of 2'-substituted chalcons to the activity of substances with regard to their position // Journal of Almanac of Modern Science and Technology Education, No. 2 (116), 2017, pp. 55-60. (article, CIS).
5. Akbarhodzhaeva Kh.N., Alimkhodzhaeva NT, Minavarova Sh.A., Bizhanova AB. The change in the phospholipid (PL) composition of the liver and immunocompetent organs of rats during xenobiotic intoxication // Journal of Young Scientist. No. 16 (150), Part I, 2017, рр. 1-5. (article, CIS).
6. Ziyamutdinova ZK, Akbarkhodzhaeva Kh. N., Yuldashov SI, Masharipov I.O. Correcting effect of membrane stabilizers and antioxidants // Journal of Young Scientist. No. 14 (148), Part III, 2017, pp. 225-227. (article, CIS).
7. Karimova Sh.F., Yuldashev NM, Ismayilova GO, Nozimshiniyeva MA. Sensitivity of thyroidocytes of growing rats to thyroid-stimulating hormone of pituitary gland with different iodine maintenance // Journal of Pediatrics. № 1, 2017, pр.138-139. (article, L).
8. Ismailova G.O. Pedagogical innovative technology of a subject of biochemistry on the basis of modular training // "Application and efficiency of modern technologies in the higher medical education" Republican educational-methodical conference. Collection of articles and abstracts. January 6, 2017. TashPMI. Tashkent. Pp. 228-235. (article, L).
9. Ismailova GO, Yuldashev NM. Application and effectiveness of modern technologies in higher medical education of independent work of students on modular training // "Application and efficiency of modern technologies in higher medical education" Republican educational-methodical conference. Collection of articles and abstracts. January 6, 2017. TashPMI. Tashkent. pp. 235-240. (article, L).
10. Ziyamutdinova ZK, Akbarhodzhaeva Kh.N., Janalieva G.A. "Eritmalarni tibbyotdagi ahamiyati" Mavzusini pedagogy tekhnolar vositasida tashkil kilish // "Application and efficiency of modern technologies in higher medical education" Republican educational and methodical conference. Collection of articles and abstracts. January 6, 2017. TashPMI. Tashkent. Pp. 201-203. (article, L).
11. Ismailova G.O., Suleymanova G.G., Madiev Yu.R. Classical method of quantitative determination of the total amount of biologically active coumarinic components in the plant organs of white melon // Periodical scientific collection "Modern trends in the development of science and technology" based on the materials of the XXII International Scientific and Practical Conference, Belgorod, January 31, 2017, No. 1, part 2, pp. 70-72. (thesis, CIS).
12. Ismailova GO, Bakhodirova M.O. Biological activity of 3-amino, 6-fluoro-3 ', 4'-ethylenedioxyflavone // "Trends and innovations of modern science" materials of the XIX International Scientific and Practical Conference (March 29, 2017). Theses of reports, Krasnodar. p. 30. (Thesis, CIS).
13. Ismailova GO, Solibaeva NO, Eldosheva P.Zh. Hepatoprotective activity of 3-amino, 6-fluoro-3', 4'-ethylenedioxyflavone. // "Trends and Innovations of Modern Science" materials of the XIX International Scientific and Practical Conference (March 29, 2017). Theses of reports, Krasnodar. 29. (Thesis, CIS).
14. Ismailova GO, Makhammadkosimova ZB. Cytoprotective activity of 3-amino, 6-chloro-3', 4'-ethylenedioxyflavone // // "Trends and Innovations of Modern Science" materials of the XIX International Scientific and Practical Conference (29 March 2017). Theses of reports, Krasnodar. С. 28. (Thesis, CIS).
2018
1. Alimkhodzhaeva N.T., Akbarhodjaeva H.N. Biochemical correction of membrane structure and functions during intoxication with hepatotropic xenobiotics. // International scientific journal "Young Scientist". - Kazan, Russia. - 2018. - No. 21 (207). - С. 166-169. (article, CIS).
2. Ismailova G.O. An interactive new method on the biochemical processes taking place in the cells "what, where and how?" // "Reforms in medical education - a criterion of development of our country's medical sector", Resp. learning style. conf., ToshPTI. - Tashkent, 2018. -86-87 pages. (thesis, M).
3. Ismailova GO, Yuldashev NM Experimental methods of interrogating the biochemical processes occurring in cells. // "Reforms in medical education - a criterion of development of our country's medical sector", Resp. learning style. conf., ToshPTI. - Tashkent, 2018. -87-88 pages. (thesis, M).
4. Karimova Sh.F. On the technology of mastering the subject "biochemistry" through modular training // "Reforms in medical education - a criterion of development of our country's medical sector", Resp. learning style. conf., ToshPTI. - Tashkent, 2018. -105-106 pages. (thesis, M).
5. Rasulova M.T., Yuldashev N.M. Morphological state of the thyroid gland due to the benzonal effect of liver monuksigenase inductor. Materials of the XXVII Theoretical Conference of students, clinical interns and young scientists "Actual problems of medicine". - Urganch, 2018. - 378-379 pages. (thesis, M).
6. Rasulova M.T., Yuldashev N.M. Tireodnyy status organism pri benzonalovoy induktsii monuksigenaznoy sistemy (MOS) pecheni // Materials of the XXVII theoretical conference of students, clinical interns and young scientists "Actual problems of medicine". - Urganch, 2018. - 380 pages. (thesis, M).
Dissertations
Over the past period made one doctoral dissertation.
Khaibullina Zarina Ruslanovna in 2012 defended his doctoral thesis at the Institute of Biochemistry, Academy of Sciences of Uzbekistan in Tashkent on "Molecular mechanisms of damage biomembranes under the reactive oxygen species during hypoxia." Specialty code 03.00.04 - Biochemistry. A 015.16.01. Scientific Director - Doctor of Medicine, Professor Ibrahim WC
The results obtained and their novelty: in the late periods posthypoxic period set mezhorgannaya relationship of the brain and liver, and its contribution to the worsening effects of cerebral ischemia. Set contribution excess generation of ROS and violations of phospholipid content in the mitochondrial fraction of liver in the development of apoptosis of hepatocytes in posthypoxic period and anti-apoptotic effect nanodoz fenozana, established part of the membrane component of the microsomal fraction of the liver in posthypoxic adaptive reactions and nanodoz modulating effect of alpha-tocopherol on antioxidant enzyme system (AOS ) in early posthypoxic period. Set primary effect of synthetic water-soluble antioxidant nanodoz fenozana in brain tissue by enzymatic chain EPA with further reduction of oxidized phospholipids and optimization of conditions for the development of the brain.
Practical value: prognostic severity scale developed cerebral ischemia neonatal nanodoz justified use of antioxidants in experimental fetal hypoxia.
The degree of implementation and cost-effectiveness: the obtained results are introduced in the form of guidelines and information letter in RSNPMTS Pediatrics RSNPMTS Obstetrics and Gynecology, and TIAME TashPMI.
Scope: biochemistry, pediatrics.
Cooperation Department
The scientific work of the department is working closely with the Department of Biochemistry of TMA, Department of Clinical and laboratory TIAME, Institute of Bioorganic Chemistry of the Republic of Uzbekistan., The Institute of Biochemical Physics, Russian Academy of Sciences (Moscow), the Department of Biochemistry of Urgench branch of TMA.
Grants, membership in scientific organizations and editorial boards
From 2012 to 2014, the Department is working on a grant ADSS 30.3 "Development of a method of enhancing the healing of myocardial necrotic lesions in the experiment ," Head - prof . NM Yuldashev .
Scientific authority of the department confirmed that Academician TS Saatov for 10 years headed the Specialized Council D 015.16.01 for doctoral and master's theses at the Institute of Biochemistry , Academy of Sciences of Uzbekistan , Professor NM Yuldashev to 2012 he was scientific secretary of the Joint Council Divisional D 087.09.02 TMA for doctoral and master's theses , currently is a member of Ed. board of the journal "Cardiology Uzbekistan" , expert of Ministry of Health and the Uzbek Academy of Sciences , member of the Advisory Board for the examination of textbooks and teaching aids Ministry of Higher Education . Currently, members of the department Acad. TS Saatov is a member of the Specialized Council 03.00.01 , biochemistry , biophysics and radiobiology at the Institute of Bioorganic Chemistry, Prof. . NM Yuldashev MD ZR Khaibullina are members of the Divisional Council 17. 4 - Pathological physiology , forensic medicine and hygiene at TMA, And ZR Haibullina - the Chairman of problem Commission of Tashkent pediatric medical Institute for medico-biological disciplines.
Inventions
Implemented in practical public health 1 patent, 5 methodical recommendations, 3 newsletters, 1 improvement suggestion.
|
№ |
Name |
Form |
Issue |
Аuthors |
|
1 |
Way of modeling allergic myocarditis |
Patent |
№ 5776 1999 |
Karimov H.YA., |
|
2 |
New model |
Methodical recommendation |
Tashkent, 2000. 8р. |
Karimov H.YA., |
|
3 |
Remedy hepato-renal failure in crush syndrome in the prepubertal period |
Newsletter |
Tashkent, 2002. 3р. |
Rakhmatullayev FH, |
|
4 |
A way to restore the hepatic blood flow in crash - syndrome in prepubertal period |
Newsletter |
Tashkent, 2002. 3р. |
Rakhmatullayev FH, |
|
5 |
Methodological approaches to the modeling of myocardial necrosis in rats |
Methodical recommendations |
Tashkent, 2004. 6р. |
Azizov A. S., |
|
6 |
Modeling metabolic a ches who syndrome in rabbits. |
Methodical recommendations |
Tashkent, 2006. 11p. |
Karimov H. J., |
|
7 |
Modern aspects of the metabolic syndrome. |
Methodical recommendations |
Tashkent, 2006. 28p. |
Karimov H. J., |
|
8 |
Separation Methods of experimental animals individually - metabolic characteristics of the organism |
Methodical recommendations |
Tashkent, 2006. 21 p |
Saidov AB, |
|
9 |
A method of predicting the risk of hypoxic-ischemic brain damage in newborn |
Rat. offer |
certificate № 82 |
Khaibullina ZR |
|
10 |
The effectiveness of glycine in the correction of abnormalities in myocardial infarction.
|
Newsletter. |
The beetle. No. 10-1493, "Extremum-Press", TSK, street Bogishamol b |
Yuldashev N. M., Ismailovа G O., Karimovа Sh. F., Nishantaev K. M. |
Student Scientific Society Chair
Department operates on Students' Scientific Society and the circle "Young biochemist." SSS members are actively engaged in scientific work, published abstracts of papers at the institute TashPMI, at national and international conferences SSS. Scientific Activities of the circle "Young biochemist": free-radical processes in the body in different diseases.
Scientific publications of Students' Scientific Society
2017 - 2018
1. Bakhodirova M.O., 211 - group, II - pediatric faculty. Scientific adviser: Ismailova G.O. Flavonoidal medicinal plant of Uzbekistan // "Khalk bilan mulokot wa inson manfaatlari iili" ha bahishlangan Talabalar ilmiye jamiyatining 45 - ilmiy - amaliy anzhumani tezislar with muds. Tashkent, April 20, 2017. P. 90. (Thesis, M).
2. Harisova I.I., 313 - group, I - pediatric faculty. Scientific adviser: Ismailova G.O. Bioscreening of the synthesized chalcon derivative // "Khalk bilan mulokot wa inson manfaatlari iili" ha bahishlangan Talabalar ilmiye jamiyatining 45 - ilmiy - amaliy anzhumani tezislar with muds. Tashkent, April 20, 2017. S. 475. (Thesis, M).
3. Kamolova A.A., 212 - group, II - pediatric faculty. Scientific adviser: Yuldashev N.M. Analysis of the absorption capacity of the preparation based on silk fibroin, taking into account its molecular structure. // "Khalk bilan mulokot wa inson manfaatlari iili" ha bahishlangan Talabalar ilmiye jamiyatining 45 - ilmiy - amaliy anzhumani tezislar with muds. Tashkent, April 20, 2017. P. 191. (thesis, M).
4. Atavullaeva M.A., 212 - group, II - pediatric faculty. Supervisor: Nishantaev M.K. A study of the absorption capacity of a preparation based on silk fibroin in relation to cholesterol // "Khalk bilan mulokot wa inson manfaatlari iili" ha bahishlangan Talabalar ilmiye jamiyatining 45 - ilmiy - amaliy anzhumani tezislar with muds. Tashkent, April 20, 2017. S. 84. (thesis, M).
5. Madiev Yu.R., 206 - group, medical-pedagogical faculty and medical business. Supervisor: Karimova Sh.F. Morphological changes in the thyroid gland of suckling suckers after the thyroidectomy of the lactating rat // "Khalk bilan mulokot wa inson manfaatlari iili" ha bahishlangan Talabalar ilmiye jamiyatining 45 - ilmiy - amaliy anzhumani tezislar with muds. Tashkent, April 20, 2017. S. 233. (thesis, M).
6. Kamalova N.N., 210 - group, I - pediatric faculty. Scientific adviser: Ziyamutdinova Z.K. The importance of phospholipids and gangliosides as structural units of membranes // "Khalk bilan mulokot wa inson manfaatlari iili" ha bahishlangan Talabalar ilmiye jamiyatining 45 - ilmiy - amaliy anzhumani tezislar with muds. Tashkent, April 20, 2017. S. 196. (thesis, M).
7. Karimova Sh.F., Ismailova GO, Karimova NM, Bizhanova A.B. Experimental study of the sensitivity of thyroid gland cells to rat thyroid-stimulating hormone for various iodine maintenance. // International scientific journal "Development and urgent issues of modern science". - Magnitogorsk, Russia. - 2018. - No. 1 (8). - P. 122-127. (article, CIS).
8. Alimkhodjaeva NT, Akbahodzhayeva Kh.N., Tajibaeva D.Sh., Menglieva I.A. Change in the activity of enzymes of carbohydrate metabolism in experimental hepatitis. // International scientific journal "Young Scientist". - Kazan, Russia. - 2018. - No. 21 (207). - P. 159-162. (article, CIS).
9. Alimkhodjaeva NT, Akbahodzhaeva Kh.N., Tajibaeva D.Sh., Menglieva I.A. Correction of the activity of the enzymes of the antioxidant system (SOD, catalase) in heliotrope hepatitis. // International scientific journal "Young Scientist". - Kazan, Russia. - 2018. - No. 21 (207). - P. 163-166. (article, CIS).
10. Ziyamutdinova Z.K., Sadriddinova M.A., Boltayev B.M. Correcting action of membranstabilizers and antioxidants. // Monthly international scientific journal "INTERNATIONAL SCIENCE PROJECT" - Turku, Finland. -2018. - 1 part, №10. -FROM. 50-52. (article, CIS).
11. Ismailova GO, Shoyunusov SI, Suleimanova GG Effective methods for the synthesis of homologues of pseudobaptygenin. // Collection. mater. XXXVII International Scientific and Practical. conferences "Actual scientific research 2018". - Moscow, 2018. - April 27. - P. 74-76. (thesis, CIS).
12. Yuldashev NM, Ismailova GO, Abdurazzakova R.S. Public information policy in the context of information psychological attacks // Materials of the International scientific-practical conference "Communication with youth: problems and solutions". Tashkent, 2018. - January 25. - pages 246-248. (thesis, M).
13. Yuldashev NM, Ismailova GO, Abdurazzakova R.S. Events on the prevention of offenses among youth // Materials of the International scientific-practical conference "Dialogue with youth: problems and solutions" - Tashkent, 2018. - January 25. - pages 382-385. (thesis, M).
14. Sobirova M.G., Ismailova G.O. Peschanaya akasiya konolli - flavonoidonosnoe lekarstvennoe rastenie Uzbekistan // Collection of theses of the 46th Scientific Conference of Students Scientific Society of TashPMI devoted to the "Year of Support to Active Business, Innovation Ideas and Technologies". - Tashkent, 2018. - 307-309 pages. (thesis, M).
15. Lutfullaev F.Sh., Karimova Sh.F. Different iodine supply and sensitivity of rat pituitary thyrotropocytes to the administration of TTG. // The 46th theoretical conference of students' scientific society TashPMI dedicated to "The Year of Support of Effective Business, Innovation Ideas and Technologies". - Tashkent, 2018. - 182-183 pages. (thesis, M).
16. Shoyunusov SI, Karimova Sh.F. Separate parameters for the metabolism of fetuses and newborn rats depending on the functional state of the thyroid gland of the pregnant and lactating female // The 46th theoretical conference of students' scientific society TashPMI dedicated to "The Year of Support of Effective Business, Innovation Ideas and Technologies". - Tashkent, 2018. - 418-419 pages. (thesis, M).
17. Gulomjonov FSh, Suleymanova G.G. The role of cardiac glycosides in medicine // "The Year of Support of Innovative Entrepreneurship, Innovative Ideas and Technologies", 46th scientifically-theoretical conference of student's scientific research institute TashPTI. - Tashkent, 2018. - 455 pages. (thesis, M).
In 2017-2018 SSS conferences were published more than 17 students' works (local and foreign publications).
Curator Mug - Dotsent Nishantaev MK
• Publishing of student works in scientific materials (see: Downloads)