07.11.2018 a clinical conference was held at the City Clinical Psychiatric Hospital of Tashkent with the participation of staff, masters and clinical residents of the departments of Tashkent Pediatric Medical Institute, TMA, Tashkent Institute of Emergency Situations and the doctors of the State Committee for Labor and Training on the differential diagnosis of mental illness. Issues of diagnosis, clinic, comorbid disorders, differential diagnosis of diseases such as F 60 Personality disorders and F 20 Paranoid schizophrenia were considered. A complex clinical case for a patient with personality disorders is presented. A clinical analysis of the patient was conducted, in which the participants of the conference actively participated. Based on anamnestic information, survey data, analysis of the characteristics of psychopathological symptoms and dynamic clinical observation, a differential diagnosis was made between personality disorder, organic brain diseases and diseases of the schizophrenic spectrum.